Anxiety, Frustration & Irritation.

My mother has been having problems with her behavior since last 4-5yrs. She has been going through menopause. My parents always had a little stressful relationship but lately she is impossible to talk and thinks that she is a victim of everything, that all of us are against her. She is very very critical and cuz her body doesnt support her due to arthritis and age catching up she stays frustated a lot. Also she isn't ready to go for therapy as she thinks it means she is crazy, but she just has a major mood issues whib has gotten worse in years. I understand that menopause can do this but it has not decreased. What am I supposed to do? I am worried that it may lead her to actually loose her mind..any suggestion's?