Thalassemia. Sir. please help me!

Hi, Treatment for patients with thalassemia major includes chronic transfusion therapy, iron chelation, splenectomy, allogeneic hematopoietic transplantation, and supportive measures. Emerging therapies include pharmacologic agents that induce fetal hemoglobin and gene therapy aimed at delivering the beta globin gene into cells by a viral vector. Splenectomy is recommended when the calculated annual transfusion requirement is greater than 200-220 mL RBCs/kg/y with a hematocrit value of 70%.The purpose of splenectomy is to reduce the transfusion requirements and the resultant iron overload. Splenectomy also prevents extramedullary hematopoiesis. Patients with thalassemia minor may have bilirubin stones in their gallbladder and, if symptomatic, may require treatment. consult Physician....