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Adine-Plus Tablet
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Adine-Plus Tablet

Manufactured byDR. JOHNS LABORATORIES PVT LTD
ContainsDiclofenac (50 mg) + Paracetamol (325 mg) + Serratiopeptidase (10 mg)
Description
Adine-Plus Tablet is a painkiller and a combination of Diclofenac, Paracetamol and Serratiopeptidase. It is used to relieve pain in conditions like headache, mild migraines, muscle pain, joint pain, tooth pain, joint pain, menstrual pain, ankylosing spondylitis (pain due to fusion of bones in the spine), osteoarthritis (pain on movement due to wearing of the protective covering at the ends of the bones) and rheumatoid arthritis (body's immunity attacks the joints and damages it). Adine-Plus Tablet may cause some side effects like nausea, vomiting, stomach pain, indigestion, and heartburn. If any of these side effects persist for a long time, consult your doctor. Do not take this medicine if you are allergic to it. Adine-Plus Tablet is recommended to be taken with food to avoid an upset stomach. Your doctor may prescribe antacids along with this medicine to overcome stomach irritation. He will also decide the dose and duration of the medicine depending on your condition. Adine-Plus Tablet has to be taken with caution if you have peptic ulcers or any medical conditions of your liver and kidney. Adine-Plus Tablet may interact with alcohol and you may see an increase in the side effects such as dizziness, drowsiness, and stomach bleeding. Adine-Plus Tablet may impact or get affected by other medications. Inform your doctor about all your current medications. Do not take other medications that have Paracetamol in them without consulting your doctor. If you are pregnant, planning a pregnancy or are breastfeeding you should consult your doctor before taking this medication.
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Side effectsConcernsUsage

Side effects

Major & minor side effects for Adine-Plus Tablet

  • Diarrhoea
  • Excessive eating
  • Severe allergy
  • Nausea or Vomiting
  • Bloody and cloudy urine
  • Tiredness and weakness
  • Abdominal pain
  • Constipation
  • Skin rash
  • Unusual bleeding or bruising
  • Mouth sores
  • Indigestion

Uses of Adine-Plus Tablet

What is it prescribed for?

  • Rheumatoid Arthritis
  • Osteoarthritis
  • Ankylosing Spondylitis
  • Mild to Moderate pain
Read More
Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    You may feel pain relief within 15-30 minutes after taking Adine-Plus Tablet.
  • How long do the effects of this medicine last?
    The duration that Adine-Plus Tablet remains active in your body is generally 10-12 hours, however this might vary from person to person. Take the medicine as prescribed by your doctor.
  • Is it safe to consume alcohol while taking this medicine?
    Consumption of alcohol with Adine-Plus Tablet may lower your blood pressure and can cause dizziness, headache and changes in heart rate.
  • Is this a habit forming medicine?
    Adine-Plus Tablet has no habit-forming tendency.
  • Can this medicine be taken during pregnancy?
    Adine-Plus Tablet is not recommended for use in pregnancy. Taking this medication during pregnancy can result in heart defects in your foetus, delay in birth or may increase the risk of bleeding. Consult your doctor before taking this medicine.
  • Can this medicine be taken while breast-feeding?
    Breastfeeding mothers should avoid taking Adine-Plus Tablet since traces of the medicine pass into breast milk and can affect your infant. Discuss the benefits and risks with your doctor before taking this medicine.

Allergy

Do not take Adine-Plus Tablet if you are allergic to it. If you notice any symptoms of an allergic reaction, such as skin rash, itching/swelling (particularly of your face/tongue/throat), extreme dizziness, breathing difficulty, etc., seek emergency medical treatment.

Kidney failure

Long-term use of high doses of some painkillers may damage normal kidney function. Adine-Plus Tablet is not advised for use in individuals with severe kidney problems. People with kidney troubles should consult their doctor before taking this medicine.

Severe liver impairment

Adine-Plus Tablet is harmful to your liver when taken for a long period or in high doses. This medicine is not recommended if you have severe liver problems. Consult your doctor before taking this medicine.

Active peptic ulcer

A peptic ulcer is an open sore that occurs on the inner lining of your stomach and the upper region of your small intestine. Adine-Plus Tablet is an NSAID (nonsteroidal anti-inflammatory medicine) that can induce stomach ulcers, bleeding, or holes in the intestine if taken for a long time. This medicine is not recommended if you already have ulcers as it may worsen your condition.
Warnings for special population

Pregnancy

Adine-Plus Tablet is not recommended for use in pregnancy. Taking this medication during pregnancy can result in heart defects in your foetus, delay in birth or may increase the risk of bleeding. Consult your doctor before taking this medicine.

Breast-feeding

Breastfeeding mothers should avoid taking Adine-Plus Tablet since traces of the medicine pass into breast milk and can affect your infant. Discuss the benefits and risks with your doctor before taking this medicine.
General warnings

Long term use

Use of Adine-Plus Tablet for more than 4 weeks is not advised due to the lack of safety and efficacy for long-term use.

Surgeries

Stop taking Adine-Plus Tablet at least 10-14 days before a scheduled surgery as it may increase the risk of bleeding during and/or after the procedure.

Liver/kidney Disease

Close monitoring of liver/kidney function may be required in people with liver/kidney impairment while taking Adine-Plus Tablet due to increased risk factors.

Chronic Malnutrition

Malnutrition and fasting can increase the risk of Adine-Plus Tablet toxicity. Dose adjustment should be done based on body weight.

Gastro-intestinal toxicity

Long term use of Adine-Plus Tablet can cause damage to your stomach and intestine such as bleeding, ulceration, and perforation of the stomach or intestinal wall.

Fluid retention and edema

Close monitoring of blood pressure, electrolyte levels, and heart function are necessary if you are taking Adine-Plus Tablet as it may cause fluid retention and oedema in few cases.

Driving or Operating machinery

Adine-Plus Tablet may cause sleepiness or dizziness. Avoid driving vehicles and operating heavy machines after taking this medicine.

Missed Dose

If you have missed the scheduled dose of Adine-Plus Tablet, take it as soon as you remember. If the delay period is more than 12 hours, do not take the missed dose. Take the next dose as per schedule. Do not double the dose to make up for the missed one.

Overdose

Never take more than the prescribed dose. Seek emergency medical treatment in case you suspect an overdose of Adine-Plus Tablet.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Consumption of alcohol with Adine-Plus Tablet may lower your blood pressure and can cause dizziness, headache and changes in heart rate.
Interaction with Medicine

Carbamazepine

Methotrexate

Ramipril

Leflunomide

Aspirin

Adefovir

Apixaban

Phenytoin

Disease interactions

Asthma

Asthma is a disorder in which a person's airways become swollen and constricted, and create excess mucus. This makes it difficult to breathe. NSAIDs (non-steroid anti-inflammatory drugs) are known to trigger asthma attacks. Adine-Plus Tablet has NSAIDs in it and using it may lead to an asthma attack. Hence, This medicine should be taken with caution if you are asthmatic.

Kidney Disease

Prolonged use of high doses of Adine-Plus Tablet may cause kidney problems, such as painful urination and protein or blood in the urine. Hence, close monitoring of kidney function is necessary.

Heart Disease

Prolonged use of Adine-Plus Tablet is known to increase the risk of heart attack and stroke in people with heart problems. Hence caution should be maintained.

Bleeding disorders

Adine-Plus Tablet should be used with extreme caution if you have pre-existing bleeding disorders as this medicine interferes with the clot formation process and increases the risk of excessive bleeding.
Food interactions
Information not available.
Lab interactions

5-HIAA Urine Test

Adine-Plus Tablet can interfere with a urine test and give a false-positive result. Hence inform your doctor and lab technician about this tablet.
This is not an exhaustive list of possible drug interactions. You should consult your doctor about all the possible interactions of the drugs you’re taking.
Take Adine-Plus Tablet with food to avoid an upset stomach. Do not break, crush or chew the tablet. Take this medicine exactly as prescribed by your doctor. Do not take this medication for a longer duration than suggested by your doctor. Consult your doctor before you stop taking this medication. Report any unusual symptoms to your doctor right away. This medicine may cause dizziness and sleepiness. Do not drive or do any task that requires mental focus until you know how Adine-Plus Tablet affects you. Avoid consuming alcohol as it may cause excessive drowsiness, increase the risk of liver damage and bleeding in your stomach.
Miscelleneous

To be taken with food

To be taken as instructed by doctor

May cause sleepiness

How it works
Adine-Plus Tablet is a combination of three medicines: Diclofenac, Paracetamol, and Serratiopeptidase. Diclofenac works by reducing the formation of certain substances in your body that are responsible for causing pain and swelling. Paracetamol increases the pain threshold (ability to handle pain) and decreases swelling. Serratiopeptidase reduces redness and swelling through the breakdown of proteins present at the site of the swelling.
Legal Status

Unknown

Unknown

Unknown

Unknown

Classification

Category

Nonsteroidal anti-inflammatory agents , Miscellaneous analgesics

Schedule

Schedule H

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https://pubchem.ncbi.nlm.nih.gov/substance/347911427>

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https://pubchem.ncbi.nlm.nih.gov/compound/Diclofenac>

Drugs, H., 2021. Acetaminophen: MedlinePlus Drug Information. [online] Medlineplus.gov. Available at: < [Accessed 27 July 2021].

https://medlineplus.gov/druginfo/meds/a681004.html>

Medicines.org.uk. 2021. Diclofenac Sodium 50mg Gastro-Resistant Tablets - Summary of Product Characteristics (SmPC) - (emc). [online] Available at: < [Accessed 27 July 2021].

https://www.medicines.org.uk/emc/product/2660>

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Information on this page was last updated on 27 Sep 2021

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