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Mosapride
Description
Mosapride is a Gastroprokinetic agent that increases the movement of food from the stomach to the intestine. It speeds up the process of gastric emptying and prevents reflux of food into the food pipe.
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Side effects
Major & minor side effects for Mosapride
Diarrhea
Abdominal pain and cramps
Dizziness
Headache
Nausea
Sleeplessness
Dry mouth
Loss of appetite
Unusual tiredness and weakness
Yellowing of skin and eyes
Irregular heartbeat
Skin rash, hives, or itching
Uses of Mosapride
What is it prescribed for?
Gastroesophageal Reflux Disease
This medicine is used to treat severe heartburn, acidity, indigestion, and stomach pain associated with the reflux of bile or stomach acids into the food pipe.
Gastroparesis
This medicine is used for the treatment of gastroparesis, a condition where the movement of food from the stomach to the intestines is slow, resulting in delayed bowel emptying.
Adjunct prior to barium enema x-ray examination
This medicine is used along with oral gastrointestinal lavage solution as an adjunct prior to barium enema x-ray examination.
Concerns
Commonly asked questions
Onset of action
The amount of time taken by this medicine to show its effect is not clinically established.Duration of effect
The amount of time for which this medicine remains effective is not clinically established.Safe with alcohol?
Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of severe adverse effects such as nausea, headache, liver dysfunction, jaundice, fatigue, etc.Is it habit forming?
No habit forming tendencies were reported.Usage in pregnancy?
This medicine is not recommended for use in pregnant women since the safety and efficacy of use are not clinically established.Usage while breast-feeding?
This medicine is not recommended for use in breastfeeding women since the safety and efficacy of use are not clinically established.
Allergy
This medicine is not recommended for use in patients with a known allergy to mosapride or any other inactive ingredients present along with it.
Gastrointestinal haemorrhage
This medicine is not recommended for use in patients having internal bleeding in the stomach or intestines due to the increased risk of worsening of the patient's condition.
Mechanical bowel obstruction
This medicine is not recommended for use in patients having a blockage or obstruction in the intestines due to the increased risk of worsening of the patient's condition.
Warnings for special population
Pregnancy
This medicine is not recommended for use in pregnant women since the safety and efficacy of use are not clinically established.
Breast-feeding
This medicine is not recommended for use in breastfeeding women since the safety and efficacy of use are not clinically established.
General warnings
Use in elderly
This medicine should be used with extreme caution in the elderly patients since the risk of adverse effects is significantly high.
Bleeding of stomach or intestine
This medicine should not be used if gastrointestinal bleeding is evident or suspected since it may worsen the patient's condition. Symptoms of gastrointestinal bleeding may include bloody or coffee colored stools, vomiting blood, coughing up blood, etc.
Mechanical obstruction of intestine
This medicine should not be used in patients having an obstruction of the intestine since it may worsen the patient's condition. Symptoms of blockage may include severe bloating, nausea, vomiting, stomach pain and cramps, and constipation.
Other medicines
Mosapride may interact with many other medicines and may cause undesirable side effects. Hence, it is advised that you report the use of all your current medicines including supplements and herbs to the doctor before beginning treatment with this medicine.
Cardiovascular effects
This medicine is reported to have caused severe side effects on the heart and blood vessels. Extreme caution is advised while using this medicine since some of these side effects may be fatal. This risk is especially higher in patients with a history of heart diseases. Close monitoring of heart function may be necessary based on the clinical condition. Replacement with a suitable alternative may be required in some cases.
Liver disease
This medicine should be used with extreme caution in patients having an impairment of the normal liver function since it may worsen the patient's condition.
Kidney disease
This medicine should be used with extreme caution in patients having an impairment of the normal kidney function since it may worsen the patient's condition.
Missed Dose
Take the missed dose as soon as you remember. If it is almost time for the next scheduled dose, then it is advisable to skip the missed dose. Do not use extra medicine to make up for the missed dose.
Overdose
Contact your doctor immediately if an overdose with this medicine is suspected. You may require emergency medical intervention if the symptoms are severe. Symptoms may include nausea, vomiting, nervousness, headache, borborygmi, etc.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol
Description
Use of alcohol while taking this medicine increases the risk of adverse effects significantly.
Instructions
Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of severe adverse effects such as nausea, headache, liver dysfunction, jaundice, fatigue, etc.
Interaction with Medicine
Erythromycin
Haloperidol
Ketoconazole
Quinine
Amiodarone
Anticholinergic drugs
Terfenadine
Sotalol
Disease interactions
Impaired liver function
This medicine should be administered with extreme caution in patients having an impairment of normal liver function due to the increased risk of worsening of the patient's condition. Use is not recommended if the impairment is severe.
Respiratory Disorders
This medicine is not recommended for use in patients with respiratory disorders (both hypoxemia and hypercapnia). Appropriate tests should be performed to rule out respiratory failure syndrome before treatment with this medicine is initiated.
Impaired kidney function
This medicine should be administered with extreme caution in patients having an impairment of normal kidney function due to the increased risk of worsening of the patient's condition. Use is not recommended if the impairment is severe.
Food interactions
Consumption of grapefruit or grapefruit juice is not recommended during treatment with this medicine due to the increased risk of severe adverse effects such as an irregular heart rhythm, restlessness, fatigue, headache, nausea, etc.
Lab interactions
Information not available.
Take Mosapride exactly as prescribed by the doctor. Do not take in larger or smaller quantities than recommended. Contact your doctor if the symptoms do not improve after 2 weeks of administration. Report any unusual symptoms to the doctor immediately.
Miscelleneous
How it works
This medicine acts by increasing the concentration of a certain natural chemical which increases stomach muscle movement and improves gastric emptying. This helps in the faster movement of food from the stomach to the intestine.
Legal Status
Classification
Category
Gastrointestinal agents
Schedule
Schedule H
Tack J, Camilleri M, Chang L, Chey W, Galligan J, Lacy B et al. Systematic review: cardiovascular safety profile of 5-HT4 agonists developed for gastrointestinal disorders. Alimentary Pharmacology & Therapeutics [Internet]. 2012 [cited 4 August 2017];35(7):745-767. Available from:
YOSHIDA N, ITO T. Mosapride citrate (AS-4370), a new gastroproltinetic agent, is a partial 5-HT4 receptor agonist in the gut. Neurogastroenterology & Motility [Internet]. 2008 [cited 4 August 2017];6(3):197-204. Available from:
Mosapride - DrugBank [Internet]. Drugbank.ca. 2017 [cited 11 September 2017]. Available from:
Compound Report Card [Internet]. Ebi.ac.uk. 2017 [cited 11 September 2017]. Available from:
Mosapride [Internet]. Pubchem.ncbi.nlm.nih.gov. 2017 [cited 11 September 2017]. Available from:
[Internet]. 2017 [cited 13 September 2017]. Available from:
[Internet]. 2017 [cited 13 September 2017]. Available from:
Information on this page was last updated on 16 Feb 2022
Disclaimer
We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.