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Codistar (10/4 mg) Syrup
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Codistar (10/4 mg) Syrup

Manufactured byMANKIND PHARMACEUTICALS LTD
ContainsCodeine (10 mg) + Chlorpheniramine (4 mg)
Description
Codistar (10/4 mg) Syrup is a combination medicine consists of codeine and chlorpheniramine. It is used for the treatment of a dry cough and to provide relief from symptoms of allergies like a runny nose, congestion, cold, throat irritation, watery eyes, and redness of the nose. Codistar (10/4 mg) Syrup works by reduces the activity of the cough centre in the brain and by stopping the effects of histamine that causes allergic symptoms. Codistar (10/4 mg) Syrup show some side effects such as drowsiness, constipation, sweating, shortness of breath, dizziness, nausea and vomiting. Consult your doctor if these symptoms persist or bother you. Do not drive a vehicle or operate machinery after taking this medicine as it can cause drowsiness and dizziness. Avoid using this syrup if you are previously allergic to it. Codistar (10/4 mg) Syrup can be taken with or without food at the dose and duration that has been prescribed. Do not stop using it without consulting your doctor as abrupt discontinuation of this medicine may cause your symptoms to recur. If you still feel unwell after completing the treatment course, consult your doctor. Codistar (10/4 mg) Syrup is not recommended to use if you have ulcers, liver or kidney diseases as it can worsen your condition. It is recommended to consult your doctor before using Codistar (10/4 mg) Syrup if you are pregnant or breastfeeding. It is not recommended to use this medicine in children under 12 years of age. Codistar (10/4 mg) Syrup can affect your ability to think and may worsen drowsiness and dizziness if taken with alcohol so it is recommended to avoid consuming alcohol while using this medicine. Take it only as prescribed by your doctor because it can cause addiction or dependence with unregulated use.
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Side effectsConcernsUsage

Side effects

Major & minor side effects for Codistar (10/4 mg) Syrup

  • Constipation
  • Dizziness and Drowsiness
  • Confusion
  • Headache
  • Tiredness
  • Stomach pain
  • Difficulty urination
  • Rash
  • Nausea and Vomiting
  • Blurred or double vision
  • Dry mouth

Uses of Codistar (10/4 mg) Syrup

What is it prescribed for?

  • Dry Cough
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Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    Codistar (10/4 mg) Syrup starts showing its effects within 30 minutes after taking it.
  • How long do the effects of this medicine last?
    The effect of Codistar (10/4 mg) Syrup lasts for an average duration of 4 to 6 hours.
  • Is it safe to consume alcohol while taking this medicine?
    Consumption of alcohol is not recommended during treatment with Codistar (10/4 mg) Syrup due to the increased risk and severity of side effects such as dizziness, lightheadedness, fainting, etc.
  • Is this a habit forming medicine?
    Codistar (10/4 mg) Syrup may be habit-forming in some cases, especially after prolonged use.
  • Can this medicine be taken during pregnancy?
    Codistar (10/4 mg) Syrup is not recommended for use in pregnancy due to the risk of harmful effects on your foetus. Consult your doctor to discuss potential risks and benefits.
  • Can this medicine be taken while breast-feeding?
    Codistar (10/4 mg) Syrup is not recommended for use in breastfeeding. An alternate medicine may be preferred. Consult your doctor to discuss potential risks and benefits.

Allergy

Avoid using Codistar (10/4 mg) Syrup if you are previously allergic to it. Seek immediate medical attention if you notice any symptoms such as skin rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, breathing difficulty, etc.

Respiratory depression

Respiratory depression is the reduction of lung function and its oxygen exchange capacity. Codistar (10/4 mg) Syrup is not recommended for use if you have respiratory disorders due to the risk of worsening your condition.

Acute or severe bronchial asthma

Asthma is a condition where there is difficulty in breathing due to the narrowing of the airway passage of your lungs. Codistar (10/4 mg) Syrup is not recommended for use if you have asthma as it may worsen your condition.

Monoamine oxidase inhibitors (MAO)

Monoamine oxidase inhibitors (MAOI) are used in the treatment of depression. Use of Codistar (10/4 mg) Syrup is not recommended to use within 14 days after taking MAO inhibitors like selegiline or rasagiline. Using these medicines simultaneously may increase the risk of undesirable effects like drowsiness and blurred vision.

Gastrointestinal obstruction

Codistar (10/4 mg) Syrup is not recommended to use if you have a gastrointestinal blockage, such as paralytic ileus. Paralytic ileus is the obstruction in your intestine due to paralysis of the intestinal muscles. In such cases, the medication may stay in the stomach for a long time (delayed absorption) which can lead to serious side effects.

Benign prostatic hyperplasia

Codistar (10/4 mg) Syrup is not recommended for use in patients with benign prostatic hyperplasia (enlarged prostate) since it may cause increased difficulty in passing urine.
Warnings for special population

Pregnancy

Codistar (10/4 mg) Syrup is not recommended for use in pregnancy due to the risk of harmful effects on your foetus. Consult your doctor to discuss potential risks and benefits.

Breast-feeding

Codistar (10/4 mg) Syrup is not recommended for use in breastfeeding. An alternate medicine may be preferred. Consult your doctor to discuss potential risks and benefits.
General warnings

Acute alcohol intoxication

Codistar (10/4 mg) Syrup is not recommended for use in patients with acute alcohol intoxication (drinking too much alcohol in a short amount of time) exhibiting depressed vital signs due to the increased risk of severe respiratory depression and death.

Drug dependence

Codistar (10/4 mg) Syrup has the potential to cause drug dependence and abuse. This risk is especially higher if the medicine is used for a prolonged period of time. Consult your doctor if you experience any changes in mood or behaviour while taking this medication. Abrupt discontinuation is not advised because it may result in withdrawal symptoms. Withdrawal of treatment should be done gradually with close monitoring.

Intracranial pressure

Codistar (10/4 mg) Syrup is not recommended to be used if have a head injury or intracranial lesions as it can increase the intracranial pressure (pressure inside the skull and on the brain) and worsen your condition.

Epilepsy

Caution is advised while using Codistar (10/4 mg) Syrup if you have epilepsy or fits because it increases the risk of seizures. Report any unusual symptoms to the doctor immediately. Your doctor may adjust the dose or replace it with a suitable alternative based on your clinical condition.

Liver/Kidney diseases

Caution is advised while using Codistar (10/4 mg) Syrup if you have liver/kidney disease due to an increase in the risk of undesirable effects. Close monitoring of the clinical condition, appropriate dose adjustments, or replacement with a suitable alternative may be necessary based on your clinical condition.

Driving or operating heavy machinery

It is advised that you do not perform any activities that require high mental alertness like driving a vehicle or operating heavy machinery after using Codistar (10/4 mg) Syrup as it increases the risk of symptoms such as drowsiness, dizziness, impaired thinking, etc.

Infectious diarrhoea

Codistar (10/4 mg) Syrup should be used with caution if you suffer from infectious diarrhoea due to the increased risk of worsening your condition. Your doctor may adjust the dose or replace it with a suitable alternative based on your clinical condition.

Use in geriatrics

Codistar (10/4 mg) Syrup should be used with caution in the elderly patients due to the increased risk of severe adverse effects. Close monitoring of clinical condition, appropriate dose adjustments, or replacement with a suitable alternative may be required based on the clinical condition.

Use in paediatrics

Codistar (10/4 mg) Syrup is not recommended for use in children less than 12 years of age. For adolescent patients, it should be used with extreme caution due to the increased risk of severe adverse effects. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Missed Dose

Take the missed dose of Codistar (10/4 mg) Syrup as soon as you remember. If your next dosage is near, skip the missed dose. Do not double your dose to compensate for a missed one.

Overdose

Never take more than the prescribed dose. Seek emergency medical attention if you suspect that you might have taken an overdose of Codistar (10/4 mg) Syrup.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Consumption of alcohol is not recommended during treatment with Codistar (10/4 mg) Syrup due to the increased risk and severity of side effects such as dizziness, lightheadedness, fainting, etc.
Interaction with Medicine

Aripiprazole

Linezolid

Monoamine oxidase inhibitors

Anxiolytics

Ramelteon

Alvimopan

Disease interactions

Hypotension

Hypotension is low blood pressure. Codistar (10/4 mg) Syrup may potentially lower your blood pressure. It is recommended to monitor your blood pressure while using this medicine.

Hypothyroidism

Codistar (10/4 mg) Syrup should be used with caution if you have thyroid disorders as it may cause hypothyroidism (reduced thyroid levels).

Seizure disorders

A seizure is an electrical disturbance in the brain that occurs spontaneously. It can alter your behaviour, actions, or emotions, as well as your level of consciousness. Codistar (10/4 mg) Syrup may aggravate seizures or fits if taken in larger doses.

Arrhythmias

Codistar (10/4 mg) Syrup should be used with caution if you have heart disease like arrhythmias due to the increased risk of bradycardia (a slow heart rate). Your doctor may adjust the dose or replace it with a suitable alternative based on your clinical condition.

Asthma

Codistar (10/4 mg) Syrup is not recommended if you have asthma because it may increase the risk of further lung problems such as respiratory tract blockage. This risk is especially higher in elderly patients.
Food interactions
Information not available.
Lab interactions
Information not available.
This is not an exhaustive list of possible drug interactions. You should consult your doctor about all the possible interactions of the drugs you’re taking.
Use Codistar (10/4 mg) Syrup as advised by your doctor. You may take this medicine with or without food. Never take more than the prescribed dose. Inform your doctor if you have stomach ulcers before taking Codistar (10/4 mg) Syrup. Consult your doctor if you do not see any improvement even after 7 days of using this medicine. Keep away from the reach of children and pets. Do not use it after the expiry date. Ensure that unused medicine is disposed of properly. Do not give your medicine to other people even if their condition appears to be the same as yours.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

Causes sleepiness

How it works
Codeine reduces the activity of the cough centre in the brain which suppresses the cough reflex. Chlorpheniramine blocks the action of a natural substance called histamine which causes the symptoms of an allergy. Therefore, this combination is effective for treating cough and associated allergic symptoms.
Legal Status

Banned

Unknown

Unknown

Unknown

Classification

Category

Upper respiratory combinations, Antitussives, Antihistamines, Narcotic analgesics

Schedule

Schedule H

Accessdata.fda.gov. 2021. [online] Available at: < [Accessed 19 August 2021].

https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/207768s006lbl.pdf>

Dailymed.nlm.nih.gov. 2021. Chlorpheniramine and Codeine Liquid. [online] Available at: < [Accessed 19 August 2021].

https://dailymed.nlm.nih.gov/dailymed/archives/fdaDrugInfo.cfm?archiveid=49449>

Drugs, H., 2021. Codeine: MedlinePlus Drug Information. [online] Medlineplus.gov. Available at: < [Accessed 19 August 2021].

https://medlineplus.gov/druginfo/meds/a682065.html>

Pubchem.ncbi.nlm.nih.gov. 2021. Codeine. [online] Available at: < [Accessed 19 August 2021].

https://pubchem.ncbi.nlm.nih.gov/compound/5284371>
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Information on this page was last updated on 25 Aug 2021

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