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Losatec H (12.5/50 mg) Tablet
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Losatec H (12.5/50 mg) Tablet

Manufactured byRpg Life Sciences Ltd.
ContainsHydrochlorothiazide (12.5 mg) + Losartan (50 mg)
Description
Losatec H (12.5/50 mg) Tablet is a combination medicine consisting of Hydrochlorothiazide and Losartan. It is used for the treatment of high blood pressure. Losatec H (12.5/50 mg) Tablet decreases blood pressure by relaxing your blood vessels, promoting smooth blood flow and increasing water excretion from your body. Therefore, this medicine also reduces the risk of heart attack (a blockage of blood flow to the heart muscle) and stroke (damage to the brain from interruption of its blood supply). Losatec H (12.5/50 mg) Tablet shows some side effects like nausea, headache, dry mouth, and an upset stomach. You may experience frequent urination while taking this medicine as a result of its activity, and this is not a side effect of the medicine. Drink plenty of fluids while taking this medicine to overcome muscle weakness, dry mouth, and extreme thirst. Losatec H (12.5/50 mg) Tablet may cause dizziness, therefore avoid driving vehicles or operating machines. Rise slowly from sitting or lying position if you feel dizzy while on Losatec H (12.5/50 mg) Tablet treatment. If any of these side effects do not resolve with time or get worse, seek a doctor's consultation at the earliest. Avoid taking this medicine if you are allergic to it. Losatec H (12.5/50 mg) Tablet can be taken in the morning to avoid frequent urination at night. Do not stop taking this medicine suddenly as it can cause your blood pressure to rise, thereby increasing the risk of heart attack and stroke. Losatec H (12.5/50 mg) Tablet should be used with caution if you have a kidney problem, liver condition, or diabetes. Frequent monitoring of your heart, liver, kidney functions and electrolytes levels may be required to use this medicine safely. Let your doctor know if you are taking any other medicines before starting the treatment. Losatec H (12.5/50 mg) Tablet is not recommended for use in children and pregnant women and mothers who breastfeed.
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Side effectsConcernsUsage

Side effects

Major & minor side effects for Losatec H (12.5/50 mg) Tablet

  • Increased urination
  • Itching or rash
  • Abdominal pain
  • Dry mouth
  • Weakness
  • Nausea and Vomiting
  • Fast heartbeat
  • Chest pain
  • Dizziness
  • Diarrhoea
  • Swelling of face and lips
  • Headache
  • Muscle cramps
  • Sleeplessnes
  • Cough

Uses of Losatec H (12.5/50 mg) Tablet

What is it prescribed for?

  • Hypertension
Read More
Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The effect of Losatec H (12.5/50 mg) Tablet may be observed in 1-2 hours after taking this medication.
  • How long do the effects of this medicine last?
    The effect of Losatec H (12.5/50 mg) Tablet lasts for an average duration of 24 hours.
  • Is it safe to consume alcohol while taking this medicine?
    Consumption of alcohol with Losatec H (12.5/50 mg) Tablet may lower your blood pressure and can cause dizziness, headache, and changes in heart rate.
  • Is this a habit forming medicine?
    Losatec H (12.5/50 mg) Tablet has no habit forming tendency.
  • Can this medicine be taken during pregnancy?
    Use of Losatec H (12.5/50 mg) Tablet should be avoided during pregnancy (especially in the 2nd and 3rd trimester) as it may cause side effects on your foetus. Hence your doctor may advise a safer alternative with the same medicinal effect based on your clinical condition.
  • Can this medicine be taken while breast-feeding?
    It is not known whether Losatec H (12.5/50 mg) Tablet passes into breast milk. Hence is not recommended for use during breastfeeding. Your doctor may advise a safer alternative with the same medicinal effect based on your clinical condition.

Allergy

Avoid taking Losatec H (12.5/50 mg) Tablet if you are previously allergic to it. Seek immediate medical attention if you notice any symptoms of allergic reactions such as skin rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, breathing difficulties, etc.

Anuria

Anuria is a condition where the kidney is unable to produce urine. Losatec H (12.5/50 mg) Tablet should be avoided for use in people with anuria due to adverse effects.

Aliskiren

The use of Losatec H (12.5/50 mg) Tablet together with Aliskiren in the elderly population with diabetes and kidney problem may not give the desired effect but rather causes major side effects. Hence avoid using it.

Kidney disease

Do not take Losatec H (12.5/50 mg) Tablet if you have a severe renal impairment (CrCl < 30 ml/min) due to the increased risk of worsening of compromised kidneys.

Liver disease

Do not use Losatec H (12.5/50 mg) Tablet in people with a history of cholestatic jaundice (a condition of reduced bile flow from the liver to the small intestine) or liver conditions associated with prior use of this medicine.
Warnings for special population

Pregnancy

Use of Losatec H (12.5/50 mg) Tablet should be avoided during pregnancy (especially in the 2nd and 3rd trimester) as it may cause side effects on your foetus. Hence your doctor may advise a safer alternative with the same medicinal effect based on your clinical condition.

Breast-feeding

It is not known whether Losatec H (12.5/50 mg) Tablet passes into breast milk. Hence is not recommended for use during breastfeeding. Your doctor may advise a safer alternative with the same medicinal effect based on your clinical condition.
General warnings

Volume and electrolyte depletion

Losatec H (12.5/50 mg) Tablet may alter the electrolyte levels in some people having kidney and liver conditions. Close monitoring of blood pressure and electrolyte levels is recommended for such people.

Kidney diseases

There may be increased levels of urea (Azotemia) in your blood when Losatec H (12.5/50 mg) Tablet is used in people with severe renal problems. Close monitoring of kidney function is necessary while taking this medicine.

Hypotension

Losatec H (12.5/50 mg) Tablet may cause symptomatic hypotension in some people with volume depletion or those treated with high-dose diuretics. Hence, better to start the treatment at reduced doses.

Hyperkalemia

Hyperkalemia (a condition with an increase in the potassium levels in the blood) is one of the side effects of Losatec H (12.5/50 mg) Tablet. Hence, this medicine should be used with extreme caution in people using potassium-containing supplements or medicines.

Use in children

Do not use Losatec H (12.5/50 mg) Tablet in children due to the lack of safety and efficacy data.

Primary hyperaldosteronism

Losatec H (12.5/50 mg) Tablet may not be effective in treating people with primary hyperaldosteronism (Primary aldosteronism is a rare condition in which the hormone aldosterone, which regulates sodium and potassium in the blood, is overproduced, resulting in high blood pressure).

Driving or operating machines

Losatec H (12.5/50 mg) Tablet may cause dizziness and a decrease in blood pressure. Avoid performing any activities that require high mental alertness, like driving vehicles or operating machines.

Missed Dose

If you missed a dose of Losatec H (12.5/50 mg) Tablet, take it as soon as you remember. If the next dose timing is near, skip the missed dose. Take your next dose at your usual time. Do not double the dose.

Overdose

Never take Losatec H (12.5/50 mg) Tablet more than the prescribed dose. If you suspect that you might have taken an overdose of this medicine, consult your doctor at the earliest.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Consumption of alcohol with Losatec H (12.5/50 mg) Tablet may lower your blood pressure and can cause dizziness, headache, and changes in heart rate.
Interaction with Medicine

Dexamethasone

Captopril

Insulin

Antidepressants

Nonsteroidal anti-inflammatory medicines

Disease interactions

Hyperuricemia

People with kidney failure and gout need special consideration while taking Losatec H (12.5/50 mg) Tablet due to the increased risk of hyperuricemia.

Congestive heart failure

Special consideration is needed while taking Losatec H (12.5/50 mg) Tablet in people with congestive heart failure (especially in volume or sodium depletion).

Angioedema

Avoid the use of Losatec H (12.5/50 mg) Tablet in people with a history of angioedema or a family history of angioedema due to the increased risk of recurrent symptoms.
Food interactions
Avoid foods high in potassium like bananas, potatoes, etc., during treatment with Losatec H (12.5/50 mg) Tablet due to the increased risk of serious side effects.
Lab interactions
Information not available.
This is not an exhaustive list of possible drug interactions. You should consult your doctor about all the possible interactions of the drugs you’re taking.
Take Losatec H (12.5/50 mg) Tablet exactly as advised by your doctor. Drink plenty of water and electrolytes to avoid dehydration. Take Losatec H (12.5/50 mg) Tablet around the same time every day so that it is easy to remember. Try taking this medicine during the daytime to avoid frequent urination at night. It is given for the long term so do not stop taking this medicine without consulting your doctor. To get maximum benefits from the treatment, you should also adopt lifestyle changes like eating low sodium and low-fat diet, exercising regularly, quitting smoking, etc. Avoid potassium-rich foods like bananas, oranges etc. while taking Losatec H (12.5/50 mg) Tablet. Monitoring of kidney function and electrolytes levels is necessary while taking Losatec H (12.5/50 mg) Tablet. This medicine can cause dizziness, so be careful while standing up from a sitting position. Do not break, crush or chew the tablet in your mouth.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

May cause sleepiness

How it works
Losatec H (12.5/50 mg) Tablet is a combination of Hydrochlorothiazide and Losartan. Hydrochlorothiazide increases the excretion of water and sodium through your urine. Losartan relaxes the blood vessels and promotes the smooth flow of blood. Their combination is thus effective in reducing blood pressure and the stress on the heart.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Angiotensin II inhibitors with thiazides, Angiotensin receptor blockers, Thiazide diuretics, Antihypertensive combinations

Schedule

Schedule H

Medicines.org.uk. 2021. Cozaar - Comp 50/12.5mg, 100/12.5mg and 100/25mg Film-Coated Tablets - Summary of Product Characteristics (SmPC) - (emc). [online] Available at: < [Accessed 24 May 2021].

https://www.medicines.org.uk/emc/medicine/1167>

Pubchem.ncbi.nlm.nih.gov. 2021. Hydrochlorothiazide. [online] Available at: < [Accessed 24 May 2021].

https://pubchem.ncbi.nlm.nih.gov/compound/Hydrochlorothiazide>

Pubchem.ncbi.nlm.nih.gov. 2021. Losartan. [online] Available at: < [Accessed 24 May 2021].

https://pubchem.ncbi.nlm.nih.gov/compound/Losartan>
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Information on this page was last updated on 27 Oct 2021

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