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Lupigest 400 MG Tablet
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Lupigest 400 MG Tablet

Manufactured byLupin Ltd.
ContainsNatural Micronised Progesterone
Description
Lupigest 400 MG Tablet is obtained from plant sources and has a similar action to the female hormone, progesterone. It is used to correct menstrual disorders caused due to a deficiency of this hormone in the body. This medicine is also used for the prevention of endometrial hyperplasia (a condition where the female sex hormones are imbalanced and heavy bleeding or intermittent bleeding between periods are experienced).
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Side effectsConcernsUsageRelated products

Substitutes

List of substitutes for Lupigest 400 MG Tablet

Susten 400 MG Tablet SR
Sun Pharma Laboratories Ltd.

Side effects

Major & minor side effects for Lupigest 400 MG Tablet

  • Chest pain and discomfort
  • Fever and chills
  • Difficulty in passing urine
  • Breast pain and tenderness
  • Muscle or joint pain
  • White or brownish discharge from the vagina
  • Headache
  • Dizziness
  • Depression
  • Breast lumps
  • Loss of vision or blurred vision
  • Unexpected vaginal bleeding
  • Convulsions (seizures)
  • Swelling of face, lips, eyelids, tongue, hands and feet
  • Constipation or diarrhea
  • Nausea or Vomiting
  • Hot flashes
  • Hair loss or thinning of the hair

Uses of Lupigest 400 MG Tablet

What is it prescribed for?

  • Amenorrhoea
  • Endometrial hyperplasia
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Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The time taken for this medicine to show it's effect is subject to vary from one person to another.
  • How long do the effects of this medicine last?
    The duration of action of this medicine is subject to vary from one person to another.
  • Is it safe to consume alcohol while taking this medicine?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is this a habit forming medicine?
    No habit forming tendencies were reported.
  • Can this medicine be taken during pregnancy?
    This medicine is recommended for use in pregnancy only if the need is clinically established. Consult your doctor before using this medicine.
  • Can this medicine be taken while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. Discuss all the risks and benefits with your doctor before taking this medicine. Your doctor may prescribe an alternative medicine based on your clinical condition.

Allergy

This medicine is not recommended for use in patients with a known allergy to progesterone or any other inactive ingredients present along with the formulation. This medicine might contain peanut oil and should never be used by patients who are allergic to peanuts.

Abnormal vaginal bleeding

This medicine is not recommended for use if you have an abnormal vaginal bleeding episode that has not been diagnosed by a doctor. Report any menstrual irregularities to the doctor immediately.

Breast cancer

This medicine is not recommended for use in patients with breast cancer or suspected breast cancer. Patients with a family history of breast cancer should be monitored closely during treatment with this medicine.

Miscarriage

This medicine is not recommended for use if the patient has had an incomplete miscarriage or missed abortion recently.

Heart and blood vessel disorder

This medicine is not recommended for use in patients having an active or historic instance of stroke or heart attack. It should not be used by patients having an active or historic clotting disorder.

Liver disease

This medicine is not recommended for use in patients with liver diseases due to the risk of adverse effects.
Warnings for special population

Pregnancy

This medicine is recommended for use in pregnancy only if the need is clinically established. Consult your doctor before using this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. Discuss all the risks and benefits with your doctor before taking this medicine. Your doctor may prescribe an alternative medicine based on your clinical condition.
General warnings

Dizziness and drowsiness

The use of this medicine can cause dizziness, drowsiness, and impair the ability to perform tasks requiring cognition and alertness. It is advised that you do not perform any activities such as driving a vehicle or operating machinery if you experience any of these symptoms. You are advised to take the medicine at recommended times to avoid any such effect.

Blood clotting disorder

The use of this medicine may cause the formation of a blood clot in the artery or a deep vein (thromboembolism) resulting in severe to fatal adverse effects. The use of this medicine should be stopped if any such condition is confirmed.

Diabetes

This medicine should be used with caution in patients with diabetes due to the risk of worsening the patient's condition. Close monitoring of blood glucose levels is necessary while receiving the medicine. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition.

Vision abnormalities

The use of this medicine may cause blurring of vision and other effects on the eye like proptosis, diplopia, etc. Patients should be carefully examined to confirm if they can safely use this medicine. Any side effects like blurred vision, excessive drying of eyes should be reported to the doctor. It is advised that you do not perform any activities such as driving a vehicle or operating machinery if you experience any of these symptoms.

Other medicines

This medicine may interact with many other medicines and may cause severe adverse effects. Hence, it is advised that you inform the doctor about all your current medicines including any herbs and supplements before beginning treatment with this medicine.

Bone mineral density

The use of this medicine may induce bone loss and may increase the risk of fractures. This risk is especially higher in patients with a known history of osteoporosis. Close monitoring of the clinical condition, appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be necessary based on the clinical condition.

Peanut allergy

This medicine is not recommended for use if you have a known history of allergy to peanuts.

Use during pregnancy

This medicine should be used during pregnancy only when advised by the consulting doctor and the clinical evidence points towards a deficiency of luteal progesterone hormone during the early stages.

Cardiovascular disorders

The use of this medicine may increase the risk of cardiovascular diseases. Hence, this medicine should be used with caution and cardiac function monitoring is required while on this medication. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be necessary based on the clinical condition.

Missed Dose

Take the missed dose as soon as you remember unless it is almost time for the next scheduled dose. Contact your doctor if you have missed more than one dose.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Carbamazepine

Ketoconazole

Insulin

Phenobarbital

Venetoclax

Edoxaban

Fluconazole

Disease interactions

Breast cancer

This medicine is not recommended for use in patients with a known or suspected breast cancer due to the increased risk of worsening of the patient's condition. Patients with a strong family history of breast cancer should be monitored closely during treatment with this medicine.

Thromboembolism

This medicine is not recommended for use in patients having a clotting disorder, cerebrovascular disease, or active thrombophlebitis due to the increased risk of worsening of the patient's condition. Replacement with a suitable alternative may be necessary based on the clinical condition.

Depression

This medicine should be used with caution in patients with a history of depression or active depression due to the increased risk of worsening of the patient's symptoms. Close monitoring of the clinical condition, appropriate dose adjustments, or replacement with a suitable alternative may be necessary based on the clinical condition.

Retinal thrombosis

The use of this medicine may sometimes cause side effects such as loss of vision, blurred vision, or retinal vascular lesions. This risk is especially higher in patients with a history of vision problems or active vision problems. Any vision problems should be reported to the doctor on priority. Close monitoring of the clinical condition, appropriate dose adjustments, or replacement with a suitable alternative may be necessary based on the clinical condition.

Fluid Retention and edema

This medicine should be administered cautiously in patients with fluid overload or edema due to the increased risk of worsening of the patient's condition. Close monitoring of the clinical condition, appropriate dose adjustments, or replacement with a suitable alternative may be necessary based on the clinical condition.

Hyperlipidemia

This medicine should be used with extreme caution in patients with hyperlipidemia (increased fat levels in the blood) due to the risk of worsening of the patient's condition. Close monitoring of lipid levels is necessary while receiving the medicine. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition.
Food interactions
Information not available.
Lab interactions

Blood coagulation tests

Report the use of this medicine to the doctor before undergoing a test to measure the coagulation time. The use of this medicine may interfere with the test results.

Thyroid function tests

Report the use of this medicine if a thyroid function test is advised. This medicine may interfere with the test results.
This is not an exhaustive list of possible drug interactions. You should consult your doctor about all the possible interactions of the drugs you’re taking.
Take this medicine exactly as instructed by the doctor. Do not take larger amounts than prescribed. Seek emergency medical treatment in case of any side effects. Ensure that the course of treatment is completed. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

Causes sleepiness

How it works
This medicine acts by mimicking the actions of progesterone and helps in the regulation of ovulation and menstruation in women of childbearing age.
Legal Status

Approved

Unknown

Unknown

Unknown

Classification

Category

Progestins

Schedule

Schedule H

Progesterone - DrugBank [Internet]. Drugbank.ca. 2020 [cited 7 February 2020]. Available from:

https://www.drugbank.ca/drugs/DB00396

Progesterone [Internet]. Pubchem.ncbi.nlm.nih.gov. 2020 [cited 7 February 2020]. Available from:

https://pubchem.ncbi.nlm.nih.gov/compound/Progesterone
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Information on this page was last updated on 24 Feb 2020

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