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Macorate CR 500 Tablet
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Macorate CR 500 Tablet

Manufactured bySUN PHARMA LABORATORIES LTD
ContainsMagnesium Valproate
Description
Macorate CR 500 Tablet is an anticonvulsant medicine, which is used as alone or in combination with other medicines for the treatment of certain types of epilepsies; is a brain disorder characterized by symptoms like uncontrolled jerking movements and loss of consciousness. It is also used for the treatment of mania which is a mental disorder characterized by hyperactivity and mood swings. This medicine is used to prevent migraine headaches characterized by symptoms such as severe headache, eye pain, nausea, and vomiting.
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Side effectsConcernsUsageRelated products

Side effects

Major & minor side effects for Macorate CR 500 Tablet

  • Nausea and vomiting
  • Diarrhea
  • Abdominal pain
  • Increased appetite
  • Weight gain
  • Sleepiness
  • Shakiness in the legs, arms, hands, or feet
  • Itching and rash
  • Hair loss
  • Aggression or anger
  • Weakness

Uses of Macorate CR 500 Tablet

What is it prescribed for?

  • Epilepsy (Seizures)
  • Mania
  • Migraine Prophylaxis
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Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The amount of time required for this medicine to show its action is not clinically established.
  • How long do the effects of this medicine last?
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Is it safe to consume alcohol while taking this medicine?
    Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of side effects such as dizziness, difficulty in concentration, drowsiness, etc. It is advised that you do not perform any activities that require high mental alertness such as driving a vehicle or operating machinery if you consume alcohol during treatment with this medicine.
  • Is this a habit forming medicine?
    No habit-forming tendencies have been reported
  • Can this medicine be taken during pregnancy?
    This medicine is not recommended for use in pregnant women except in life-threatening conditions. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may prescribe a safer alternative based on your clinical condition.
  • Can this medicine be taken while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the drug based on your clinical condition.

Allergy

This medicine is not recommended for use in patients with a known allergy to magnesium valproate, or any other inactive ingredients present in the formulation.

Liver Disease

This medicine is not recommended for use in patients suffering from liver diseases due to the increased risk of worsening the patient's condition.

Urea cycle disorders

This medicine is not recommended for use in patients suffering from urea cycle disorders (high levels of ammonium in the blood) due to the increased risk of serious adverse effects.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women except in life-threatening conditions. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may prescribe a safer alternative based on your clinical condition.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the drug based on your clinical condition.
General warnings

Use in children

This medicine may be used for the treatment of children if the benefits significantly outweigh the risks and only under the supervision of a qualified healthcare professional.

Driving and operating machinary

This medicine may cause dizziness or drowsiness in some patients. It is advised that you do not perform any activities that require high mental alertness like driving a vehicle or operating machinery if you experience any of these symptoms during treatment with this medicine.

Suicidal ideation

This medicine may increase the risk of suicidal thoughts. Appropriate dose adjustments should be done in patients with depression or suicidal tendencies.

Use in elderly

This medicine should be used with caution in the elderly population due to the increased risk of severe adverse effects. Appropriate dose adjustments may be required based on the clinical condition.

Other medicines

This medicine may interact with many other medicines and may cause severe adverse effects. Hence, it is advised that you inform the doctor about all your current medicines including any herbs and supplements before beginning treatment with this medicine.

Missed Dose

Take the missed dose as soon as you remember. If it is almost time for the next scheduled dose then the missed dose can be skipped. Do not take a double dose to make up for the missed one.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of side effects such as dizziness, difficulty in concentration, drowsiness, etc. It is advised that you do not perform any activities that require high mental alertness such as driving a vehicle or operating machinery if you consume alcohol during treatment with this medicine.
Interaction with Medicine

Lamotrigine

Ethinyl Estradiol

Warfarin

Disease interactions

Depression

This medicine should be used with caution in patients with depression and suicidal thoughts. Frequent monitoring of depression symptoms is necessary. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition. Do not stop the use of any medicine without consulting your doctor.

Kidney disease

This medicine should be used with caution in patients with kidney diseases due to the increased risk of worsening of the patient's condition. Close monitoring of kidney function is recommended during treatment with this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition of the patient.
Food interactions
Information not available.
Lab interactions
Information not available.
This is not an exhaustive list of possible drug interactions. You should consult your doctor about all the possible interactions of the drugs you’re taking.
Take this medicine exactly as prescribed by the doctor. Do not take in larger or smaller quantities than prescribed. Do not change the initial formulation prescribed without consulting your doctor. Report any adverse effects experienced to the doctor on priority. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

May cause sleepiness

How it works
This medicine works by restores the balance of certain natural substances in the brain to control and prevent the symptoms of seizures, mania, and migraine headaches.
Legal Status

Approved

Unknown

Unknown

Unknown

Classification

Category

Anticonvulsants, Antimigraine agents

Schedule

Schedule H

Magnesium valproate [Internet]. Pubchem.ncbi.nlm.nih.gov. 2020 [cited 30 June 2020]. Available from:

https://pubchem.ncbi.nlm.nih.gov/compound/Magnesium-valproate

[Internet]. Medind.nic.in. 2020 [cited 30 June 2020]. Available from:

http://medind.nic.in/daa/t09/i1/daat09i1p126.pdf

NCATS Inxight: Drugs — VALPROATE MAGNESIUM [Internet]. Drugs.ncats.io. 2020 [cited 30 June 2020]. Available from:

https://drugs.ncats.io/drug/Q400352CM2
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Information on this page was last updated on 8 Jul 2020

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.