Home >
Medicine Info >
Megapose Plus Tablet
Loading interface...

Megapose Plus Tablet

Manufactured byMANKIND PHARMACEUTICALS LTD
ContainsFlupenthixol (0.5 mg) + Escitalopram (10 mg)
Description
Megapose Plus Tablet is a combination medicine used in the treatment of patients suffering from both depression and anxiety disorders. This medicine is not recommended for use in patients below 18 years of age.
QUICK LINKS:
Side effectsConcernsUsage

Side effects

Major & minor side effects for Megapose Plus Tablet

  • Restlessness
  • Shaking and trembling of arms and feet
  • Changes in weight
  • Drowsiness or sleepiness
  • Decreased interest in sexual intercourse
  • Confusion
  • Convulsions
  • Decreased urine output
  • Constipation
  • Dry mouth
  • Excessive air or gas in stomach
  • Decreased appetite
  • Joint pain

Uses of Megapose Plus Tablet

What is it prescribed for?

  • Comorbid Depression and Anxiety Disorder
Read More
Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The amount of time required for this medicine to show its action is not clinically established.
  • How long do the effects of this medicine last?
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Is it safe to consume alcohol while taking this medicine?
    Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of serious adverse effects such as drowsiness, dizziness, difficulty with concentration and memory, impaired thinking and judgment, etc.
  • Is this a habit forming medicine?
    No habit forming tendency has been reported.
  • Can this medicine be taken during pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
  • Can this medicine be taken while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. If the medicine is used, the infant should be monitored closely for any adverse effects.

Allergy

This medicine is not recommended for use in patients with a known allergy to flupenthixol, any other thioxanthenes, escitalopram, or any other inactive ingredients present along with the formulation.

Severe Depression

This medicine is not recommended for use in patients suffering from severe depression and requiring hospitalization.

Monoamine oxidase inhibitors

This medicine is not recommended for use in patients undergoing treatment with Monoamine Oxidase Inhibitors (MAOIs) such as selegiline, moclobemide etc. There should be a time gap of at least 14 days between stopping treatment with MAOIs and beginning treatment with this medicine to avoid their interaction.

Pimozide

This medicine is not recommended for use in patients undergoing treatment with pimozide due to an increased risk of heart rhythm disorders.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. If the medicine is used, the infant should be monitored closely for any adverse effects.
General warnings

Neuroleptic malignant syndrome (NMS)

This medicine should be used with extreme caution due to the increased risk of neuroleptic malignant syndrome. Report any symptoms such as an increased heart rate, increased breathing rate, fever, changes in mood or behavior, etc. to the doctor immediately. Close monitoring of the clinical condition, appropriate patient/caregiver counseling, dose adjustments, or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Other coexisting diseases

This medicine may affect the treatment of many other diseases such as diabetes, cardiovascular diseases, lung diseases, kidney diseases, liver diseases, etc. It is advised that you report to the doctor all your past medical history as well as your current medical conditions before beginning treatment with this medicine.

Driving or operating machinery

This medicine may cause symptoms such as weakness, drowsiness, sleepiness, dizziness, etc. in some patients. It is advised that you do not perform any activities such as driving a vehicle or operating heavy machinery if you experience any of these symptoms.

Use in children

This medicine is not recommended for use in patients below 18 years of age since the safety and efficacy of use are not clinically established.

Diabetes

This medicine should be used with caution in patients with a known history of diabetes due to the increased risk of altered blood glucose levels. Close monitoring of blood glucose levels is recommended for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be necessary in some cases based on the clinical condition.

Bleeding disorders

This medicine may increase the risk of abnormal bleeding in some patients. This risk is especially higher in patients with a history of bleeding disorders and patients undergoing treatment with aspirin, NSAIDs, anticoagulants, etc. Report any unusual bleeding or bruising, blood in the stool, etc. to the doctor immediately. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition.

Suicidal tendencies

This medicine may cause suicidal behavior in some patients. This risk is especially higher on the prolonged usage of the medicine. Patients should be monitored closely for any changes in behavior and mood; any such changes should be reported to the doctor immediately. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Missed Dose

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose. Do not double your dose to make up for the missed dose.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of serious adverse effects such as drowsiness, dizziness, difficulty with concentration and memory, impaired thinking and judgment, etc.
Interaction with Medicine

Clarithromycin

Ketoconazole

Levodopa

Phenobarbital

Metoclopramide

Disease interactions

Parkinson's disease

This medicine should be used with extreme caution in patients suffering from Parkinson's disease due to the increased risk of worsening of the patient's condition. Close monitoring of the patient's clinical condition, appropriate dose adjustments, or replacement with a suitable alternative may be necessary in some cases.

Seizure disorders

This medicine should be used with extreme caution in patients with seizure disorders due to the increased risk of recurrent seizures. Treatment should be discontinued if the patient develops seizures or if there is an increase in the frequency of seizures in patients with a previous diagnosis of epilepsy. An alternative treatment option should be considered in such cases based on the clinical condition.
Food interactions
Information not available.
Lab interactions
Information not available.
This is not an exhaustive list of possible drug interactions. You should consult your doctor about all the possible interactions of the drugs you’re taking.
Take medicine with or without food. Do not take in larger amounts than advised. Consult the doctor if you experience any undesirable effects. Do not stop taking the medicine without consulting your doctor as it may cause withdrawal symptoms.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

May cause sleepiness

How it works
Flupenthixol blocks the actions of certain natural substances that are responsible for causing symptoms associated with depression. Escitalopram works by increasing the amount of a chemical substance in the brain which helps in maintaining the psychological balance.
Legal Status

Banned

Unknown

Unknown

Unknown

Classification

Category

Antipsychotics, Selective Serotonin reuptake inhibitors

Schedule

Schedule H

Escitalopram: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2017 [cited 17 August 2018]. Available from:

https://medlineplus.gov/druginfo/meds/a603005.html

Flupentixol - DrugBank [Internet]. Drugbank.ca. 2020 [cited 20 June 2020]. Available from:

https://www.drugbank.ca/drugs/DB00875

Flupentixol [Internet]. Pubchem.ncbi.nlm.nih.gov. 2020 [cited 20 June 2020]. Available from:

https://pubchem.ncbi.nlm.nih.gov/compound/Flupentixol
Loading related questions...
Something doesn’t feel right?
Report an error

Information on this page was last updated on 1 Jul 2020

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.