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Napra-D-500 Tablet
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Napra-D-500 Tablet

Manufactured byINTAS PHARMACEUTICALS LTD
ContainsNaproxen (500 mg) + Domperidone (10 mg)
Description
Napra-D-500 Tablet is a combination of Naproxen and Domperidone used to treat migraine headaches (intense pounding headaches that occur usually on one side of the head). This medicine blocks the action of chemical substances in your body that cause pain, thus helpful in treating migraine. It also blocks the action of a chemical substance in your brain that causes nausea associated with migraine. Napra-D-500 Tablet shows side effects like headache, stomach pain, dry mouth, and diarrhoea. If any of these side effects persist or worsen, consult your doctor at the earliest. Avoid taking this medicine if you are allergic to it. Napra-D-500 Tablet may cause dizziness, drowsiness, or visual disturbances in some cases. Maintain caution while driving vehicles or performing activities that require concentration if you take this medicine. Avoid consuming alcohol while taking this medicine as it can increase your risk of stomach problems. Napra-D-500 Tablet should be taken with food or milk to prevent an upset stomach. Avoid taking more than the recommended dose. Your doctor may regularly monitor your kidney and liver function, and levels of blood components if you are taking this medicine for long-term treatment. Napra-D-500 Tablet is not suitable for everyone. Inform your doctor if you have heart, liver, or kidney problems, or clotting disorders (blood does not clot normally, causing excessive bleeding) to make sure this medicine is safe for you. Also, inform your doctor if you are taking any other medicines to avoid undesired effects. Consult your doctor if you are pregnant, planning a pregnancy, or are breastfeeding.
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Side effectsConcernsUsage

Side effects

Major & minor side effects for Napra-D-500 Tablet

  • Swelling of face, lips, eyelids, tongue, hands and feet
  • Difficulty in breathing
  • Skin rash
  • Convulsions (seizures)
  • Dry mouth
  • Decreased sexual urge
  • Stomach pain
  • Diarrhoea
  • Dizziness
  • Change in appetite
  • Irregular menstrual periods
  • Drowsiness
  • Visual disturbances
  • Irregular heartbeat

Uses of Napra-D-500 Tablet

What is it prescribed for?

  • Migraine
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Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The time taken for Napra-D-500 Tablet to show its effect is not known.
  • How long do the effects of this medicine last?
    The time duration for which Napra-D-500 Tablet remains active in the body is not known.
  • Is it safe to consume alcohol while taking this medicine?
    Consumption of alcohol is not recommended during treatment with Napra-D-500 Tablet as it can increase the risk of stomach and intestinal bleeding
  • Is this a habit forming medicine?
    No habit-forming tendencies were reported for Napra-D-500 Tablet.
  • Can this medicine be taken during pregnancy?
    Napra-D-500 Tablet is not recommended for use during pregnancy, especially during the last three months, as it can harm your developing foetus and also cause complications during delivery.
  • Can this medicine be taken while breast-feeding?
    Napra-D-500 Tablet passes into the breastmilk and may harm your baby. Hence, consult your doctor if you are breastfeeding.

Tumor of pituitary gland

The pituitary gland is a small pea-sized gland that plays a major role in regulating vital body functions and general wellbeing. Napra-D-500 Tablet is not recommended for use if you have a tumour of the pituitary gland as it may worsen your condition.

Heart diseases

Napra-D-500 Tablet may cause an irregular heartbeat. Hence, this medicine is not recommended if you have pre-existing heart conditions like congestive heart failure (a condition in which your heart is not able to pump sufficient blood throughout the body), QT prolongation (heart muscle takes longer than normal to recharge between a heartbeat), etc., as it may worsen your condition. Also, it is not recommended for use before and after coronary artery bypass surgery (a surgical procedure that is performed to restore normal blood flow to the heart), as it may increase the risk of other complications.

Allergy

Avoid taking Napra-D-500 Tablet if you are allergic to this medicine. Seek medical attention if you experience symptoms such as a skin rash, hives (itchy, painful eruptions that sting), swelling (especially of the face, lips, tongue, etc.), breathing difficulty, etc.

NSAID-induced asthma

NSAIDs (Non-steroidal anti-inflammatory drugs) are a class of medications used to relieve pain and swelling. NSAID-induced asthma is an allergic condition that causes narrowing of the airways due to the use of NSAIDs. Napra-D-500 Tablet is not recommended for use if you have a history of NSAID-induced asthma as it may further worsen your condition.

Peptic ulcer

Peptic ulcers are open sores on the inner lining of your stomach and the upper region of your small intestine. Napra-D-500 Tablet is not recommended for use if you have peptic ulcers, as this medicine may cause stomach bleeding and worsen your condition.

Moderate to severe liver impairment

Napra-D-500 Tablet gets broken down in the liver. Impaired liver function may cause an accumulation of this medicine in the body and increase the risk of undesired effects. Therefore, it is not recommended for use if you have moderate to severe liver problems as it can cause further liver damage and worsen your condition.
Warnings for special population

Pregnancy

Napra-D-500 Tablet is not recommended for use during pregnancy, especially during the last three months, as it can harm your developing foetus and also cause complications during delivery.

Breast-feeding

Napra-D-500 Tablet passes into the breastmilk and may harm your baby. Hence, consult your doctor if you are breastfeeding.
General warnings

Other medicines

Napra-D-500 Tablet may interact with many other medicines and cause severe side effects. Hence, inform the doctor about all your current medicines, including any herbs and supplements, before beginning treatment with Napra-D-500 Tablet.

Effect on heart

Napra-D-500 Tablet may cause an increase in blood pressure and fluid retention (abnormal build-up of fluid in the body). Hence, it should be used with caution if you have heart problems due to the increased risk of heart-related complications. Your heart function and vital signs will be closely monitored by your doctor while you are taking this medicine.

Electrolyte imbalance

Napra-D-500 Tablet should be used with extreme caution if you have electrolyte imbalance due to the increased risk of other complications.

Skin allergies

Napra-D-500 Tablet may cause serious skin reactions in some cases. Inform your doctor immediately if you develop signs and symptoms such as rashes, hives (itchy, painful eruptions that sting), skin lesions (a part of the skin that has an abnormal growth or appearance), or other allergic symptoms.

Use in the elderly

Napra-D-500 Tablet should be used with caution in the elderly due to an increase in the risk of undesired effects.

Prolactin imbalance

Using high doses of Napra-D-500 Tablet for a longer period may cause an imbalance in the prolactin levels in the body, resulting in disturbances in the menstrual cycle in women.

Driving or operating machines

Napra-D-500 Tablet may cause dizziness, drowsiness, or blurred vision. Avoid performing activities that require mental alertness, such as driving vehicles or operating machines, if you experience such symptoms after taking this medicine.

Use in children

Napra-D-500 Tablet is not recommended for use in children below 12 years of age as the safety and efficacy data are not available.

Bleeding disorder

Napra-D-500 Tablet may inhibit the formation of blood clots and prolong the bleeding time. Hence, this medicine should be used with extreme caution if you have active bleeding or clotting disorders (blood does not clot normally, causing excessive bleeding).

Missed Dose

Take the missed dose of Napra-D-500 Tablet as soon as you remember. If it is time for your next dose, skip the missed dose. Do not double your dose to make up for the missed dose.

Overdose

Never take more than the prescribed dose. Seek emergency medical treatment in case of an overdose of Napra-D-500 Tablet.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Consumption of alcohol is not recommended during treatment with Napra-D-500 Tablet as it can increase the risk of stomach and intestinal bleeding
Interaction with Medicine

Cisapride

Erythromycin

Ketoconazole

Ramipril

Tramadol

Warfarin

Ketorolac

Bromocriptine

Prednisolone

Disease interactions

Kidney Disease

Napra-D-500 Tablet should be used with extreme caution if you have kidney problems, as this medicine may further increase the risk of kidney toxicity. Your doctor will suggest tests to monitor your kidney function while you are taking this medicine.

Liver Disease

Napra-D-500 Tablet should be used with extreme caution if you have liver problems. This medicine may cause an increase in liver enzyme levels and further increase the risk of liver toxicity. Your doctor will suggest tests to monitor your liver function while you are taking this medicine.

Intestinal Disorders

Long term use of Napra-D-500 Tablet can cause damage to the stomach and intestine. Serious conditions like bleeding, ulceration, and perforation of the stomach or intestinal wall can occur. Any symptom indicating ulceration and bleeding like indigestion, the appearance of coffee-coloured dry blood in stools, or vomiting of blood should be reported to your doctor immediately.
Food interactions
Information not available.
Lab interactions
Information not available.
This is not an exhaustive list of possible drug interactions. You should consult your doctor about all the possible interactions of the drugs you’re taking.
Take Napra-D-500 Tablet as advised by your doctor. Drink plenty of water to avoid stomach irritation. Do not break, crush, or chew the tablet. Avoid taking more or less than the recommended dose. Take this medicine for the recommended duration for better results. Keep Napra-D-500 Tablet away from the reach of children and pets. Avoid using it after the date of expiry. Inform your doctor if you notice any undesirable effects that persist or worsen, or if your symptoms are not improving after taking a few doses of Napra-D-500 Tablet.
Miscelleneous

To be taken after food

To be taken as instructed by doctor

May cause sleepiness

How it works
Napra-D-500 Tablet is composed of Naproxen and Domperidone. Naproxen works by blocking the formation of certain chemical substances in the body that cause pain and swelling. Domperidone works by blocking the action of a chemical in the brain and helps to prevent nausea often associated with migraine.
Legal Status

Unknown

Unknown

Unknown

Unknown

Classification

Category

Nonsteroidal anti-inflammatory agents, Prokinetic agent

Schedule

Schedule H

Dailymed.nlm.nih.gov. 2022. Wal-Mart Naproxen Sodium Tablets, 220 mg Drug Facts. [online] Available at: < [Accessed 27 January 2022].

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=5d9e5081-38b5-449c-9d78-e6e2445e3d38>

Drugs, H., 2022. Naproxen: MedlinePlus Drug Information. [online] Medlineplus.gov. Available at: < [Accessed 27 January 2022].

https://medlineplus.gov/druginfo/meds/a681029.html>

Pubchem.ncbi.nlm.nih.gov. 2022. Domperidone. [online] Available at: < [Accessed 27 January 2022].

https://pubchem.ncbi.nlm.nih.gov/compound/3151#section=Top>

migraine, L., support, H., options, T. and medicines, A., 2022. Acute medicines - The Migraine Trust. [online] The Migraine Trust. Available at: < [Accessed 17 February 2022].migraine, L., support, H., options, T. and medicines, A., 2022. Acute medicines - The Migraine Trust. [online] The Migraine Trust. Available at: <https://migrainetrust.org/live-with-migraine/healthcare/treatments/acute-medicines/> [Accessed 17 February 2022].

https://migrainetrust.org/live-with-migraine/healthcare/treatments/acute-medicines/>

Ruh.nhs.uk. 2022. [online] Available at: < [Accessed 17 February 2022].

https://www.ruh.nhs.uk/patients/patient_information/NEU007_Domperidone_NSAID_for_Migrane.pdf>

agent, n., Disorders, M., drugs, n., agent, n., material, g., chloride, s. and derivatives, a., 2022. GB2313309A - Domperidone and NSAIDs for the treatment of migraine - Google Patents. [online] Patents.google.com. Available at: < [Accessed 17 February 2022].

https://patents.google.com/patent/GB2313309A/en>
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Information on this page was last updated on 21 Feb 2022

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