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Olkem Trio 6.25 Tablet
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Olkem Trio 6.25 Tablet

Manufactured byALKEM LABORATORIES LTD
ContainsChlorthalidone (6.25 mg) + Cilnidipine (10 mg) + Olmesartan (20 mg)
Description
Olkem Trio 6.25 Tablet is an anti-hypertensive (blood pressure lowering) medicine that consists of Chlorthalidone, Cilnidipine, and Olmesartan. It is used for the treatment of hypertension (high blood pressure). Olkem Trio 6.25 Tablet works by relaxing the blood vessels and increasing the water and sodium excretion from the body, thus controlling your blood pressure. It may also reduce the risk of heart attack (a blockage of blood flow to the heart muscle) or stroke (a condition that causes damage to the brain due to interrupted blood supply) by promoting the smooth flow of blood throughout your body. Olkem Trio 6.25 Tablet shows some common side effects like swelling in your ankles or feet, back pain, headache, nausea, diarrhoea, and stomach pain. Most of these side effects are temporary and usually resolve with time. Olkem Trio 6.25 Tablet can also cause sleepiness and dizziness, so avoid driving vehicles or operating machines after taking this medicine. Avoid consuming alcohol during treatment with this medicine as it can worsen dizziness. Olkem Trio 6.25 Tablet can be taken with or without food. The dose will be determined by your doctor depending on your blood pressure levels. Do not stop using this medicine without consulting your doctor, as abrupt discontinuation may cause an elevation in blood pressure and increase the risk of other complications. Maintain a strict diet regimen and exercise regularly along with taking this medicine to get the best possible effect. Olkem Trio 6.25 Tablet is not recommended for use if you are allergic to it. If you have pre-existing kidney or liver problems or any other medical conditions, consult your doctor before taking this medicine. Inform your doctor about all medicines and supplements you are taking, as this medicine can interact with them and cause side effects. Olkem Trio 6.25 Tablet is not recommended for use in children below 18 years of age. Consult your doctor if you are pregnant, or are breastfeeding.
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Side effectsConcernsUsageRelated products

Side effects

Major & minor side effects for Olkem Trio 6.25 Tablet

  • Headache
  • Unusual tiredness and weakness
  • Dry mouth
  • Chills
  • Swelling of face, lips, eyelids, tongue, hands and feet
  • Muscle pain
  • Skin rash
  • Increased urination frequency
  • Stomach pain
  • Low blood pressure
  • Diarrhoea
  • Nausea and Vomiting
  • Dizziness
  • Blurred vision

Uses of Olkem Trio 6.25 Tablet

What is it prescribed for?

  • Hypertension
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Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The effect of Olkem Trio 6.25 Tablet can be observed within 2 hours after intake.
  • How long do the effects of this medicine last?
    Olkem Trio 6.25 Tablet remains active in the body for approximately 24 hours.
  • Is it safe to consume alcohol while taking this medicine?
    Consumption of alcohol is not recommended during treatment with Olkem Trio 6.25 Tablet due to the increased risk of dizziness, fainting, and very low blood pressure levels. It is advised that you do not perform any activity that requires high mental alertness, like driving vehicles or operating machines, if you experience any of these symptoms.
  • Is this a habit forming medicine?
    No habit-forming tendencies were reported for Olkem Trio 6.25 Tablet.
  • Can this medicine be taken during pregnancy?
    Olkem Trio 6.25 Tablet is not recommended for use in pregnancy as it may harm your foetus. Consult your doctor if you are pregnant.
  • Can this medicine be taken while breast-feeding?
    Olkem Trio 6.25 Tablet may pass into breastmilk. Hence, consult your doctor if you are breastfeeding.

Allergy

Avoid taking Olkem Trio 6.25 Tablet if you are allergic to any of the ingredients present in the medicine. Seek immediate medical attention if you experience symptoms such as skin rash, hives (painful eruptions that sting), swelling (face, lips, tongue, etc.), breathing difficulty, etc.

Aliskiren

It is not recommended to take Olkem Trio 6.25 Tablet and Aliskiren (a medicine used in the treatment of high blood pressure) together as this may lead to kidney damage, low blood pressure, and high potassium levels in the blood. It may also cause other undesirable effects such as irregular heartbeat, muscle paralysis, heart attack, etc. This risk is especially higher in the elderly and if you have diabetes and/or kidney problems.

Anuria

Olkem Trio 6.25 Tablet is not recommended if you have anuria (a condition where the kidney is unable to produce urine), as it may further damage your kidneys.
Warnings for special population

Pregnancy

Olkem Trio 6.25 Tablet is not recommended for use in pregnancy as it may harm your foetus. Consult your doctor if you are pregnant.

Breast-feeding

Olkem Trio 6.25 Tablet may pass into breastmilk. Hence, consult your doctor if you are breastfeeding.
General warnings

Use in the elderly

Olkem Trio 6.25 Tablet should be used with caution in the elderly due to the increased risk of low blood pressure. Regular monitoring of blood pressure levels is necessary while using this medicine.

Use in Children

Olkem Trio 6.25 Tablet is not recommended for use in children less than 18 years of age as the safety and efficacy data are not available.

Hypotension

Hypotension is the condition where your blood pressure is lower than normal. Olkem Trio 6.25 Tablet is not recommended for use if you have hypotension, as it may further decrease your blood pressure and worsen your condition.

Liver Disease

Olkem Trio 6.25 Tablet should be used with extreme caution if you have liver problems due to the increased risk of side effects. Your doctor may recommend tests to monitor your liver function, if necessary, while you are on treatment with this medicine.

Volume and electrolyte disturbances

Olkem Trio 6.25 Tablet may alter the blood volume and electrolyte levels. This may cause dizziness, dry mouth, and acid-base imbalance (abnormality in the body to balance between acid and base). This risk is especially higher if you have kidney or liver problems. Your blood pressure and electrolyte levels will be closely monitored by your doctor while you are on this medication.

Kidney Disease

Olkem Trio 6.25 Tablet should be used with caution if you have kidney problems due to the increased risk of worsening your condition. Your doctor may adjust the dose of this medicine or suggest a suitable alternative based on your condition. Also, your doctor may recommend tests to monitor your kidney function, if necessary, while you are on treatment with this medicine.

Driving or operating machines

Olkem Trio 6.25 Tablet may cause symptoms such as drowsiness, blurred vision, or dizziness. Avoid performing activities that require high mental alertness like driving vehicles or operating heavy machines during treatment with this medicine.

Hyperkalaemia

Olkem Trio 6.25 Tablet may lead to hyperkalaemia (increased potassium levels in the blood). This may cause side effects such as cardiac rhythm irregularities. It is advised to avoid potassium-rich foods (potatoes, bananas) and other medicines that may increase potassium levels (ACE inhibitors and potassium supplements) during treatment with this medicine.

Missed Dose

Take the missed dose of Olkem Trio 6.25 Tablet as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume at the scheduled time. Do not double your dose to make up for the missed one.

Overdose

Seek emergency medical treatment if you suspect that you might have taken an overdose of Olkem Trio 6.25 Tablet.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Consumption of alcohol is not recommended during treatment with Olkem Trio 6.25 Tablet due to the increased risk of dizziness, fainting, and very low blood pressure levels. It is advised that you do not perform any activity that requires high mental alertness, like driving vehicles or operating machines, if you experience any of these symptoms.
Interaction with Medicine

Cisapride

Lithium

Amiodarone

Insulin

Disease interactions

Congestive heart failure

Congestive heart failure is a condition in which your heart does not pump enough blood to meet the demands of your body. Olkem Trio 6.25 Tablet should be used with caution if you have congestive heart failure as it may worsen your condition. Your doctor may closely monitor your heart function while you are taking this medicine.

Diabetes

Olkem Trio 6.25 Tablet should be used with caution if you have diabetes (a condition that results in high blood sugar levels) due to the increased risk of altered blood sugar levels. Monitor your blood sugar levels regularly during treatment with this medicine.

Hyperuricaemia

Olkem Trio 6.25 Tablet should be used with caution if you have hyperuricaemia (a condition that causes increased uric acid levels in your blood). This medicine may decrease the excretion of uric acid from the body, thus increasing its level in your blood.

Hyperlipidaemia

Olkem Trio 6.25 Tablet may increase the blood cholesterol and fats levels. Hence, it should be used with caution if you have hyperlipidaemia (a condition that leads to high levels of cholesterol and fats in the blood). Your doctor may closely monitor your cholesterol and triglyceride levels during treatment with this medication.
Food interactions
Avoid consumption of grapefruit juice while taking Olkem Trio 6.25 Tablet as it can increase the absorption of this medicine in your body, thus increasing the risk of side effects.
Lab interactions
Information not available.
This is not an exhaustive list of possible drug interactions. You should consult your doctor about all the possible interactions of the drugs you’re taking.
Take Olkem Trio 6.25 Tablet with or without food. Do not crush, break, or chew the tablet in your mouth. Swallow as a whole with plenty of water. Avoid taking more or less than the prescribed dose. Do not self-medicate or stop taking this medicine on your own unless directed by your doctor. This medicine may cause dizziness. Get up slowly when rising from a sitting or lying down position. Also, avoid driving vehicles or operating machines after taking this medicine. Olkem Trio 6.25 Tablet may cause dehydration. Therefore drink plenty of fluids and inform your doctor if you experience symptoms such as extreme thirst, muscle weakness, or dry mouth. Keep the medicine away from the reach of children and pets. Do not take this medicine after the expiry date. Ensure that the unused medicine is disposed of properly.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

May cause sleepiness

How it works
Olkem Trio 6.25 Tablet is a combination of Chlorthalidone, Cilnidipine, and Olmesartan. Chlorthalidone works by increasing the excretion of water and sodium from the kidneys via urine. This helps in controlling blood pressure as well as reducing oedema (swelling caused by excess fluid trapped in your body's tissues, most often in your feet, ankles, and legs). Cilnidipine and Olmesartan both relax the blood vessels, thus improving blood flow and reducing blood pressure levels.
Legal Status

Unknown

Unknown

Unknown

Unknown

Classification

Category

Thiazide diuretics, Calcium channel blocking agents, Angiotensin receptor blockers, Antihypertensive combinations

Schedule

Schedule H

Drugs, H., 2022. Olmesartan: MedlinePlus Drug Information. [online] Medlineplus.gov. Available at: [Accessed 28 June 2022].

https://medlineplus.gov/druginfo/meds/a603006.html

Pubchem.ncbi.nlm.nih.gov. 2022. Cilnidipine. [online] Available at: [Accessed 28 June 2022].

https://pubchem.ncbi.nlm.nih.gov/compound/cilnidipine#section=Top

Pubchem.ncbi.nlm.nih.gov. 2022. Olmesartan. [online] Available at: [Accessed 28 June 2022].

https://pubchem.ncbi.nlm.nih.gov/compound/158781

Pubchem.ncbi.nlm.nih.gov. 2022. Chlorthalidone. [online] Available at: [Accessed 28 June 2022].

https://pubchem.ncbi.nlm.nih.gov/compound/2732

Dailymed.nlm.nih.gov. 2021. DailyMed - CHLORTHALIDONE tablet. [online] Available at: [Accessed 5 October 2021].

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=193c85ba-43c2-4be2-82cf-7b394a83390e

Centaurpharma.com. 2021. [online] Available at: [Accessed 31 August 2021].

https://www.centaurpharma.com/downloads/CENTAPRES.pdf
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Information on this page was last updated on 6 Jul 2022

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